Nutramedix, BABUNA - Chamomile Sleep Support

ANXIETY

Keefe, J. R., Guo, W., Li, Q. S., Amsterdam, J. D., & Mao, J.J. (2018). An exploratory study ofsalivary cortisol changes during chamomile extract therapy of moderate tosevere generalized anxiety disorder. Journal of Psychiatric Research, 96,189-195. Full Article

Amsterdam, J. D., Li, Y., Soeller, I., Rockwell, K., Mao, J. J.,& Shults, J. (2009). A randomized,double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile)extract therapy of generalized anxiety disorder. Journal of Clinical Psychopharmacology, 29(4), 378. Full Article

CANCER

Srivastava, J. K., & Gupta, S.(2007). Antiproliferative and apoptoticeffects of chamomile extract in various human cancer cells. Journal of Agricultural and Food Chemistry, 55(23), 9470-9478. Full Article

DIABETES

Emam, M. A. (2012). Comparative evaluation of antidiabeticactivity of Rosmarinus officinalis L. and Chamomile recutita in streptozotocininduced diabetic rats. Agric. Biol. JN Am, 3(6), 247-252. Full Article

ORAL MUCOSITIS

Gomes, V. T. S., Nonato Silva Gomes,R., Gomes, M. S., Joaquim, W. M., Lago, E. C., & Nicolau, R. A. (2018). Effects of Matricaria Recutita (L.) in theTreatment of Oral Mucositis. The Scientific World Journal, 2018. Full Article

Fidler, P., Loprinzi, C. L.,O'Fallon, J. R., Leitch, J. M., Lee, J. K., Hayes, D. L., ... & Michalak,J. C. (1996). Prospective evaluation ofa chamomile mouthwash for prevention of 5‐FU‐induced oral mucositis. Cancer: Interdisciplinary International Journal of the American Cancer Society, 77(3),522-525. Full Article

IRRITABLE BOWEL SYNDROME (IBS)

Asadi-Shahmirzadi, A., Mozaffari, S.,Sanei, Y., Baeeri, M., Hajiaghaee, R., Monsef-Esfahani, H. R., & Abdollahi,M. (2012). Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: Combination ofantioxidant and spasmolytic effects. Chinese Journal of Integrativemedicine, 1-9. Full Article

VARIOUS CONDITIONS

Srivastava, J. K., Shankar, E., &Gupta, S. (2010). Chamomile: a herbalmedicine of the past with a bright future. Molecular Medicine Reports, 3(6), 895-901. Full Article

Gardiner, P. (2007). Complementary, holistic, and integrativemedicine: chamomile. Pediatrics in Review, 28(4), e16. Full Article

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ANTI-ALLERGIC

Chandrashekhar, V. M., Halagali, K. S., Nidavani, R. B., Shalavadi, M. H., Biradar, B. S., Biswas, D., & Muchchandi, I. S. (2011). Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model. Journal of Ethnopharmacology, 137(1), 336-340. Full Article

ANTIBACTERIAL

M Moricz, A., Szarka, S., G Ott, P., B Hethelyi, E., Szoke, E., & Tyihak, E. (2012). Separation and identification of antibacterial chamomile components using OPLC, bioautography and GC-MS. Medicinal Chemistry, 8(1), 85-94. Full Article

ANTIDEPRESSANT

Amsterdam, J. D., Shults, J., Soeller, I., Mao, J. J., Rockwell, K., & Newberg, A. B. (2012). Chamomile (matricaria recutita) may have antidepressant activity in anxious depressed humans-an exploratory study. Alternative Therapies in Health and Medicine, 18(5), 44. Full Article

ANTIFUNGAL

Jamalian, A., Shams-Ghahfarokhi, M., Jaimand, K., Pashootan, N., Amani, A., & Razzaghi-Abyaneh, M. (2012). Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. Journal de Mycologie Médicale/Journal of Medical Mycology, 22(4), 308-315. Full Article

ANTI-INFLAMMATORY

Begum, N. (2017). In vitro investigation of anti-inflammatory and COX-2 inhibitory potential of flower extracts of Matricaria recutita. International Journal of Green Pharmacy (IJGP), 11(02). Full Article

Bhaskaran, N., Shukla, S., Srivastava, J. K., & Gupta, S. (2010). Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity. International Journal of Molecular Medicine, 26(6), 935-940. Full Article

Srivastava, J. K., Pandey, M., & Gupta, S. (2009). Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sciences, 85(19-20), 663-669. Full Article

ANTISEIZURE

Heidari, M. R., Dadollahi, Z., Mehrabani, M., Mehrabi, H., Pourzadeh‐Hosseini, M., Behravan, E., & Etemad, L. (2009). Study of antiseizure effects of Matricaria recutita extract in mice. Annals of the New York Academy of Sciences, 1171(1), 300-304. Full Article

ANTIMICROBIAL

Göger, G., Demirci, B., Ilgın, S., & Demirci, F. (2018). Antimicrobial and toxicity profiles evaluation of the Chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agents. Industrial Crops and Products, 120, 279-285. Full Article

Abd El Raheim, M., Alam, A., Nour, Y. S., & Radwan, A. M. (2016). Evaluation of Antimicrobial and Antioxidant activities of Matricaria recutita, Ricinus communis and Zygophyllum coccineum Extracts. Bull. Env. Pharmacol. Life Sci, 5, 30-33. Full Article

Kazemi, M. (2015). Chemical composition and antimicrobial activity of essential oil of Matricaria recutita.International Journal of Food Properties, 18(8), 1784-1792. Full Article

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ANTIOXIDANT

Hwang, S. H., Wang, Z., Quispe, G., Yanymee, N., Lim, S. S., & Yu, J. M. (2018). Evaluation of Aldose Reductase, Protein Glycation, and Antioxidant Inhibitory Activities of Bioactive Flavonoids in Matricaria recutita L. and Their Structure-Activity Relationship. Journal of Diabetes Research, 2018. Full Article

Hajaji, S., Sifaoui, I., López-Arencibia, A., Reyes-Batlle, M., Jiménez, I. A., Bazzocchi, I. L., ... & Akkari, H. (2017). Correlation of radical-scavenging capacity and amoebicidal activity of Matricaria recutita L.(Asteraceae).Experimental parasitology, 183, 212-217. Full Article

Hashemi, S. M. B., Brewer, M. S., Safari, J., Nowroozi, M., Abadi Sherahi, M. H., Sadeghi, B., & Ghafoori, M. (2016). Antioxidant activity, reaction mechanisms, and kinetics of Matricaria recutita extract in commercial blended oil oxidation. International Journal of Food Properties, 19(2), 257-271. Full Article

Sebai, H., Jabri, M. A., Souli, A., Hosni, K., Rtibi, K., Tebourbi, O., ... & Sakly, M. (2015). Chemical composition, antioxidant properties and hepatoprotective effects of chamomile (Matricaria recutita L.) decoction extract against alcohol-induced oxidative stress in rat. General Physiology and Biophysics, 34(3), 263-275. Full Article

Sebai, H., Jabri, M. A., Souli, A., Rtibi, K., Selmi, S., Tebourbi, O., ... & Sakly, M. (2014). Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats. Journal of Ethnopharmacology, 152(2), 327-332. Full Article

Pereira, R. P., Fachinetto, R., de Souza Prestes, A., Puntel, R. L., Da Silva, G. N. S., Heinzmann, B. M., ... & Morsch, V. M. (2009). Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus. Neurochemical Research, 34(5), 973-983. Full Article

ANTIPRURITIC

Kobayashi, Y., Takahashi, R., & Ogino, F. (2005). Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice. Journal of Ethnopharmacology, 101(1-3), 308-312. Full Article

Kobayashi, Y., Nakano, Y., Inayama, K., Sakai, A., & Kamiya, T. (2003). Dietary intake of the flower extracts of German chamomile (Matricaria recutita L.) inhibited compound 48/80-induced itch-scratch responses in mice.Phytomedicine, 10(8), 657-664. Full Article

ANTIVIRAL

Koch, C., Reichling, J., Kehm, R., Sharaf, M. M., Zentgraf, H., Schneele, J., & Schnitzler, P. (2008). Efficacy of anise oil, dwarf‐pine oil and chamomile oil against thymidine‐kinase‐positive and thymidine‐kinase‐negative herpesviruses. Journal of Pharmacy and Pharmacology, 60(11), 1545-1550. Full Article

ANXIOLYTIC

Viola, H., Wasowski, C., De Stein, M. L., Wolfman, C., Silveira, R., Dajas, F., ... & Paladini, A. C. (1995). Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Medica, 61(03), 213-216. Full Abstract

LEISHMANICIDAL ACTIVITY

Hajaji, S., Sifaoui, I., López-Arencibia, A., Reyes-Batlle, M., Jiménez, I. A., Bazzocchi, I. L., ... & Piñero, J. E. (2018). Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil. Parasitology Research, 1-13. Full Article

NEUROPROTECTIVE ACTIVITY

Ranpariya, V. L., Parmar, S. K., Sheth, N. R., & Chandrashekhar, V. M. (2011). Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. Pharmaceutical Biology, 49(7), 696-701. Full Article

Chandrashekhar, V. M., Ranpariya, V. L., Ganapaty, S., Parashar, A., & Muchandi, A. A. (2010). Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats. Journal of Ethnopharmacology, 127(3), 645-651. Full Article

PAIN RELIEF

Zargaran, A., Borhani-Haghighi, A., Salehi-Marzijarani, M., Faridi, P., Daneshamouz, S., Azadi, A., ... & Mohagheghzadeh, A. (2018). Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study. Neurological Sciences, 1-9. Full Article

RELAXANT

Sándor, Z., Mottaghipisheh, J., Veres, K., Hohmann, J., Bencsik, T., Horváth, A., ... & Csupor, D. (2018). Evidence supports tradition: the in vitro effects of Roman Chamomile on smooth muscles. Frontiers in Pharmacology, 9, 323. Full Article

VARIOUS PROPERTIES

Petronilho, S., Maraschin, M., Coimbra, M. A., & Rocha, S. M. (2012). In vitro and in vivo studies of natural products: A challenge for their valuation. The case study of chamomile (Matricaria recutita L.). Industrial Crops and Products, 40, 1-12. Full Article

“Seems to help with sleep. Very convenient. I use it sublingually sometimes if I wake up too early” – C.T

“I really didn't expect this to work very well and was very pleased to find that it's really very effective and I only take three drops per night.” – M.J

"I use this every night and it works great for me, I don't feel that sleeping med drowsiness in the morning either."-R.I.

"Absolutely fantastic! Me and my teenage daughter couldn't cope without it. Closes off any 'brainwaves' and allows you to go to sleep within 20 minutes." -E.H.

15 Drops in 4 oz. of water at bedtime.  Repeat during the night as needed. Can also be used at a dose of 10-15 drops during the day as needed for anxiety.

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Babuna did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article